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GrainGenes Reference Report: TAG-135-679

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Reference	TAG-135-679
Title	Identification and characterization of a natural polymorphism in FT-A2 associated with increased number of grains per spike in wheat
Journal	Theoretical and Applied Genetics
Year	2021
Volume	135
Pages	679-692
Author	Glenn P [ Show all 8 ]
Abstract	Increases in wheat grain yield are necessary to meet future global food demands. A previous study showed that loss-of-function mutations in FLOWERING LOCUS T2 (FT2) increase spikelet number per spike (SNS), an important grain yield component. However, these mutations were also associated with reduced fertility, offsetting the beneficial effect of the increases in SNS on grain number. Here, we report a natural mutation resulting in an aspartic acid to alanine change at position 10 (D10A) associated with significant increases in SNS and no negative effects on fertility. Using a high-density genetic map, we delimited the SNS candidate region to a 5.2-Mb region on chromosome 3AS including 28 genes. Among them, only FT-A2 showed a non-synonymous polymorphism (D10A) present in two different populations segregating for the SNS QTL on chromosome arm 3AS. These results, together with the known effect of the ft-A2 mutations on SNS, suggest that variation in FT-A2 is the most likely cause of the observed differences in SNS. We validated the positive effects of the A10 allele on SNS, grain number, and grain yield per spike in near-isogenic tetraploid wheat lines and in an hexaploid winter wheat population. The A10 allele is present at very low frequency in durum wheat and at much higher frequency in hexaploid wheat, particularly in winter and fall-planted spring varieties. These results suggest that the FT-A2 A10 allele may be particularly useful for improving grain yield in durum wheat and fall-planted common wheat varieties.
External Databases	https://doi.org/10.1007/s00122-021-03992-y
Allele	FT-A2 A10 (Triticum)
Gene	FT-A2 (Triticum) bZIPC1 (Triticum)
Probe	FT-A2 D10A CAPS
Summarized in	Glenn P and Dubcovsky J MAS Wheat. Bringing Genomics to the Wheat Fields. Spikelet number per spike gene bZIPC1 MAS Wheat. Marker Assisted Selection in Wheat.

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