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GrainGenes Reference Report: MBR-41:6

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Reference	MBR-41:6
Title	Identification of genetic loci and candidate genes related to Beta-glucan content in barley grain by genome-wide association study in International Barley Core Selected Collection
Year	2021
Volume	41
Author	Geng L [ Show all 6 ]
Abstract	Beta-glucan is an important trait to be improved in barley breeding programs, as it greatly affects the quality of the end products when barley grains are used as raw material of feed or malt production or consumed as food for human. Although the genes associated with Beta-glucan synthesis have been identified, genetic regulation of Beta-glucan accumulation in barley grains is still completely unclear. In this study, 100 accessions from International Barley Core Selected Collection (BCS) were planted in two environments for two consecutive years to determine the genotypic variation of grain Beta-glucan content. A genome-wide association study (GWAS) identified 14 stable marker-trait associations (MTAs) (-Log10(P)> 4) for grain Beta-glucan content. Significantly positive correlation was found between grain Beta-glucan content and the number of favorable alleles of 14 stable MTAs. Seven putative candidate genes encoding some enzymes in glucose metabolism were found to be associated with Beta-glucan content. One of the putative genes, HORVU6Hr1G088380, could be an important gene controlling barely Beta-glucan content, with the SNPs being closely linked in all tested accessions and divided into two haplotypes. High resolution melting (HRM) analysis of the first SNP suggested that the HRM-SNP marker is valid for marker-assisted selection in barley breeding. This study provides useful information for the genes and markers related to grain Beta-glucan content in barley.
External Databases	https://doi.org/10.1007/s11032-020-01199-5
Cited in	Du B et al. (2024) Detection of consensus genomic regions and candidate genes for quality traits in barley using QTL meta-analysis Frontiers in Plant Science 14.

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