GrainGenes Reference Report: NGN-39-623
Reference
NGN-39-623
Title
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase.
Journal
Nature Genetics
Year
2007
Volume
39
Pages
623-630
Author
Song X-J Huang W Shi M Zhu M-Z Lin H-X
Abstract
Grain weight is one of the most important components of grain yield and is controlled by quantitative trait loci (QTLs) derived from natural variations in crops. However, the molecular roles of QTLs in the regulation of grain weight have not been fully elucidated. Here, we report the cloning and characterization of GW2, a new QTL that controls rice grain width and weight. Our data show that GW2 encodes a previously unknown RING-type protein with E3 ubiquitin ligase activity, which is known to function in the degradation by the ubiquitin-proteasome pathway. Loss of GW2 function increased cell numbers, resulting in a larger (wider) spikelet hull, and it accelerated the grain milk filling rate, resulting in enhanced grain width, weight and yield. Our results suggest that GW2 negatively regulates cell division by targeting its substrate(s) to proteasomes for regulated proteolysis. The functional characterization of GW2 provides insight into the mechanism of seed development and is a potential tool for improving grain yield in crops.
External Databases
https://doi.org/10.1038/ng2014
Gene
TaGW2-A1
Summarized in
MAS Wheat. Bringing Genomics to the Wheat Fields. Yield. Thousand Grain Weight - Grain Size. TaGW2-A1 MAS Wheat. Marker Assisted Selection in Wheat.
GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture.
GrainGenes Reference Report: NGN-39-623
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GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture. | |||