GrainGenes Reference Report: TBS-23-174
Reference
TBS-23-174
Title
Role of the CCAAT-binding protein CBF/NF-Y in transcription
Journal
Trends in Biochemical Sciences
Year
1998
Volume
23
Pages
174-178
Remark
Discusses transcription factor / regulator : NF-YC Discusses transcription factor / regulator : NF-YB Discusses transcription factor / regulator : NF-YA
Author
Maity SN de Crombrugghe B
Abstract
The CCAAT motif is one of the common promoter elements present in the proximal promoter of numerous mammalian genes transcribed by RNA polymerase II. CBF (also called NF-Y and CP1) consists of three different subunits and interacts specifically with the CCAAT motif. In each CBF subunit, the segment needed for formation of the CBF-DNA complex is conserved from yeast to human and, interestingly, the conserved segment of two CBF subunits, CBF-A and CBF-C, are homologous to the histone-fold motif of eukaryotic histones and archaebacterial histone-like protein HMf-2. The histone fold motifs of CBF-A and CBF-C interact with each other to form a heterodimer that associates with CBF-B to form a heterotrimeric CBF molecule, which then binds to DNA.
External Databases
https://www.ncbi.nlm.nih.gov/pubmed/9612081
GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture.
GrainGenes Reference Report: TBS-23-174
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GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture. | |||