GrainGenes Reference Report: CEL-88-685
Reference
CEL-88-685
Title
A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death
Journal
Cell
Year
1997
Volume
88
Pages
685-694
Remark
Discusses transcription factor / regulator : C2C2-LSD
Author
Dietrich RA Richberg MH Schmidt R Dean C Dangl JL
Abstract
Arabidopsis Isd1 mutants are hyperresponsive to cell death initiators and fail to limit the extent of cell death. Superoxide is a necessary and sufficient signal for cell death propagation. Thus, LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. We isolated LSD1 via its map position. The predicted LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC. These domains are present in three additional Arabidopsis genes, suggesting that LSD1 defines a zinc finger protein subclass. LSD1 is constitutively expressed, consistent with the mutant phenotype. Alternate splicing gives rise to a low abundance mRNA encoding an extra five amino-terminal amino acids. We propose that LSD1 regulates transcription, via either repression of a prodeath pathway or activation of an antideath pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death.
External Databases
https://www.ncbi.nlm.nih.gov/pubmed/9054508
GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture.
GrainGenes Reference Report: CEL-88-685
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GrainGenes is a product of the Agricultural Research Service of the US Department of Agriculture. | |||