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GrainGenes Reference Report: PCP-43-177

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Reference	PCP-43-177
Title	A gene encoding multidrug resistance (MDR)-like protein is induced by aluminum and inhibitors of calcium flux in wheat
Journal	Plant and Cell Physiology
Year	2002
Volume	43
Pages	177-185
Author	Sasaki T Ezaki B Matsumoto H
Abstract	Summary: A cDNA clone exclusively induced by aluminum (Al) was isolated from root apices of wheat (Triticum aestivum L.) by the differential display method. The predicted amino acid sequence exhibited homology to the multidrug resistance (MDR) proteins that is known as a member of the ATP-binding cassette (ABC) protein superfamily. Thus this gene was named TaMDR1 (Triticum aestivum MDR). TaMDR1 was induced as a function of Al concentration in the range from 5 to 50 micromolar, which is in the range of Al content in natural acid soil environment. The concentration required for the induction was lower in the Al-sensitive cultivar than in the Al-tolerant cultivar, indicating that the accumulation of TaMDR1 mRNA was associated with the events caused by Al toxicity rather than Al tolerance. TaMDR1 was significantly induced by the exposure to lanthanum, gadolinium and ruthenium red, which are known as inhibitors of calcium channels. Furthermore, decreasing of calcium ion in growth medium caused stimulation of the gene expression. These results suggested that the induction of TaMDR1 is caused by the breaking of calcium homeostasis which occurred at early stage of Al toxicity
External Databases	Pubmed: 11867697
Keyword	[ Hide all but 1 of 57 ] abc protein abc transporters acid acid soil al al tolerance al toxicity aluminum aluminum stress amino acid amino acid sequence arabidopsis thaliana atp-binding calcium calcium channels calcium homeostasis cdna cdna clone channel clone cultivar differential display environment events exposure fluxes function gene gene expression growth growth media homeostasis homology induction inhibitor ion lanthanum mdr wheat (triticum aestivum l.) media member method mrna multidrug-resistance p-glycoprotein plasma-membrane vesicles protein resistance root root apices sequence soil stimulation superfamily tolerance toxicity triticum triticum aestivum

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