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GrainGenes Reference Report: NAR-21-2823

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Reference	NAR-21-2823
Title	Evolution of sequence repetition and gene duplications in the TATA-binding protein TBP (TFIID)
Journal	Nucleic Acids Research
Year	1993
Volume	21
Pages	2823-2830
Author	Hancock J
Abstract	Analysis of TBP gene sequences from a variety of species for clustering of short sequence motifs and for over- and underrepresentation of short sequence motifs suggests involvement of slippage in the recent evolution of the TBP N-terminal domains in metazoans, Acanthamoeba and wheat AGC, GCA and CAG are overrepresented in TBP genes of other species, suggesting that opa arrays were amplified from motifs overrepresented in ancestral species The phylogenetic distribution of recently slippage-derived sequences in TBP is similar to that observed in the large subunit ribosomal RNAs, suggesting a propensity for certain evolutionary lineages to incorporate slippage generated motifs into protein-coding as well as ribosomal RNA genes. Because length increase appears to have taken place independently in lineages leading to vertebrates, insects and nematodes, TBP N-terminal domains in these lineages are not homologous. All gene duplications in the TBP gene family appear to have been recent events despite strong protein sequence similarity between TRF and P. falciparum TBP. The enlargement of the TBP N-terminal domain may have coincided with acquisition of new functions and may have accompanied molecular coevolution with domains of other proteins, resulting in the acquisition of new or more complex mechanisms of transcription regulation.
Keyword	[ Hide all but 1 of 14 ] complementary dna dna binding-proteins drosophila-melanogaster duplication fungi multigene-families nucleotide sequence phylogeny plants repetitive dna sequence-alignment structural genes tata-box-binding-protein transcription-factors

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