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GrainGenes Reference Report: HER-87-474

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Reference	HER-87-474
Title	5-azacytidine induces chromosomal breakage in the root tips of wheat carrying the cuckoo chromosome 4S(L) from Aegilops sharonensis
Journal	Heredity
Year	2001
Volume	87
Pages	474-479
Author	las Heras JI King IP Parker JS
Abstract	Summary: The cuckoo chromosome 4S(L) from Aegilops sharonensis is preferentially transmitted when introduced by hybridization into common wheat, Triticum aestivum. Gametocidal (Gc) factors carried in 4S(L) induce chromosome breakage in meiospores not containing them, ensuring their transmission to the progeny. Chromosome breakage and break-fusion-bridge (BFB) cycles can also be observed during early embryo sac development of chromosome 4S(L) addition lines to wheat, often leading to the presence of dicentric chromosomes in the subsequent progeny. However, the process responsible for inducing the primary chromosomal breaks only appears to occur during the initial divisions of the embryo and endosperm. In the presence of chromosome 4S(L), treatment with the hypomethylating agent 5-azacytidine induces chromosome breakage in root tips. This suggests that the process of chromosome fragmentation, induced by the Gc factors during early seed development, is repressed at later stages by DNA methylation
External Databases	Pubmed: 11737296
Keyword	[ Hide all but 1 of 45 ] 5-azacytidine activation addition addition line aegilops aegilops sharonensis aestivum bfb cycles breakage chromosome chromosome breakage common common wheat cycle development division dna dna methylation embryo embryo sac endosperm endosperm development expression fragmentation gametocidal chromosomes gene activity genetic hybridization induction line methylation molecular molecular biology progeny root root tips seed seed development stage suggests transmission triticum triticum aestivum wheat x rye hybrids

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