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GrainGenes Reference Report: GNM-44-128

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Reference
GNM-44-128
Title
Different chromosomal distribution patterns of radiation-induced interchange breakpoints in barley: First post-treatment mitosis versus viable offspring
Journal
Genome
Year
2001
Volume
44
Pages
128-132
Author
Kunzel G
Gecheff KI
Schubert I
Abstract
Summary: Translocation breakpoints (TBs) induced by ionizing radiation are nonrandomly distributed along barley chromosomes. When first post-treatment mitoses were evaluated, centromeres and the heterochromatin-containing proximal segments tended to be more than randomly involved, and terminal segments to be less than randomly involved in translocations. Contrary to this, small chromosomal regions in median and distal arm positions, characterized by high recombination rates and high gene density, were identified as preferred sites for the origination of viable translocations, probably due to deviations in chromatin organization. Apparently, the position of a TB has an influence on the rate of viability versus elimination of the carrier cells. Surprisingly, TBs within centromeres and heterochromatin-containing segments seem to be more harmful for survival than those induced in gene-rich regions
Keyword
[ Hide all but 1 of 36 ]
barley
breakpoint distribution
canada
carrier
cell
centromere
chromatin
chromatin organization
chromosome
common wheat
density
elimination
gene
gene-rich regions
genetic
genome
hordeum vulgare
ionizing radiation
karyotype
mitosis
molecular biology
mutagens
nor
organization
physical map
position
radiation
radiation-induced chromosome breaks
rates
recombination
segment
site
survival
translocation
translocation lines
viability

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