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GrainGenes Reference Report: GEN-138-849

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Reference	GEN-138-849
Title	Molecular evolution of the plant R regulatory gene family
Journal	Genetics
Year	1994
Volume	138
Pages	849-859
Author	Purugganan M Wessler S
Abstract	Anthocyanin pigmentation patterns in different plant species are controlled in part by members of the myc-like R regulatory gene family We have examined the molecular evolution of this gene family in seven plant species Three regions of the R protein show sequence conservation between monocot and dicot R genes These regions encode the basic helix-loop-helix domain, as well as conserved N-terminal and C-terminal domains: mean replacement rates for these conserved regions are 1.02 X 10(-9) nonsynonymous nucleotide substitutions per site per year More than one-half of the protein, however, is diverging rapidly, with nonsynonymous substitution rates of 4.08 X 10(-9) substitutions per site per year. Detailed analysis of R homologs within the grasses (Poaceae) confirm that these variable regions are indeed evolving faster than the flanking conserved domains. Both nucleotide substitutions and small insertion/deletions contribute to the diversification of the variable regions within these regulatory genes. These results demonstrate that large tracts of sequence in these regulatory loci are evolving at a fairly rapid rate.
Keyword	[ Hide all but 1 of 17 ] amino acid sequence antirrhinum majus deletion evolution molecular sequence data multigene-families nucleotide sequence nucleotide-substitution oryza sativa pennisetum-americanum phyllostachys phyllostachys-acuta sorghum bicolor structural genes tripsacum tripsacum-australe zea mays

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