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GrainGenes Reference Report: MBR-27-439

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Reference	MBR-27-439
Title	Genome-wide association mapping of Fusarium head blight resistance in contemporary barley breeding germplasm
Journal	Molecular Breeding
Year	2011
Volume	27
Pages	439-454
Author	Massman J [ Show all 10 ]
Abstract	Utilization of quantitative trait loci (QTL) identified in bi-parental mapping populations has had limited success for improving complex quantitative traits with low to moderate heritability. Association mapping in contemporary breeding germplasm may lead to more effective marker strategies for crop improvement. To test this approach, we conducted association mapping of two complex traits with moderate heritability; Fusarium head blight (FHB) severity and the grain concentration of mycotoxin associated with disease, deoxynivalenol (DON). To map FHB resistance in barley, 768 breeding lines were evaluated in 2006 and 2007 in four locations. All lines were genotyped with 1,536 SNP markers and QTL were mapped using a mixed model that accounts for relatedness among lines. Average linkage disequilibrium within the breeding germplasm extended beyond 4 cM. Four QTL were identified for FHB severity and eight QTL were identified for the DON concentration in two independent sets of breeding lines. The QTL effects were small, explaining 1-3% of the phenotypic variation, as might be expected for complex polygenic traits. We show that using breeding germplasm to map QTL can complement bi-parental mapping studies by providing independent validation, mapping QTL with more precision, resolving questions of linkage and pleiotropy, and identifying genetic markers that can be applied immediately in crop improvement.
External Databases	https://doi.org/10.1007/s11032-010-9442-0
QTL	[ Hide all but 1 of 19 ] MetaQ.DON_1H_2 MetaQ.FHB_2H_17 MetaQ.DON_2H_21 MetaQ.DON_2H_27 MetaQ.HD_2H_13 MetaQ.HT_2H_13 MetaQ.DON_3H_3 MetaQ.HT_3H_2 MetaQ.FHB_4H_3 MetaQ.DON_4H_1 MetaQ.DON_4H_3 MetaQ.DON_4H_5 MetaQ.HT_4H_1 MetaQ.DON_5H_3 MetaQ.FHB_6H_8 MetaQ.FHB_6H_15 MetaQ.DON_6H_3 MetaQ.HD_6H_2 MetaQ.HT_6H_2

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