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GrainGenes Reference Report: PNA-103-3546

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Reference	PNA-103-3546
Title	High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats.
Journal	Proceedings of the National Academy of Sciences, USA
Year	2006
Volume	103
Pages	3546-3551
Author	[ Hide all but 1 of 10 ] Regina A Bird A Topping D Bowden S Freeman J Barsby T Kosar-Hashemi B Li ZY Rahman S Morell M
Abstract	Foods high in resistant starch have the potential to improve human health and lower the risk of serious noninfectious diseases. RNA interference was used to down-regulate the two different isoforms of starch-branching enzyme (SBE) II (SBEIIa and SBEIIb) in wheat endosperm to raise its amylose content. Suppression of SBEIIb expression alone had no effect on amylose content; however, suppression of both SBEIIa and SBEIIb expression resulted in starch containing >70% amylose. When the >70% amylose wheat grain was fed to rats in a diet as a wholemeal, several indices of large-bowel function, including short-chain fatty acids, were improved relative to standard wholemeal wheat. These results indicate that this high-amylose wheat has a significant potential to improve human health through its resistant starch content.
External Databases	https://doi.org/10.1073/pnas.0510737103
Gene Class	Amylose (resistant starch) content High amylose
Gene Set	SbeII

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