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GrainGenes Reference Report: JCS-72-25

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Reference	JCS-72-25
Title	Genome-wide association mapping of phenolic acids in tetraploid wheats
Journal	Journal of Cereal Science
Year	2017
Volume	74
Pages	25-34
Author	Nigro D [ Show all 9 ]
Abstract	Phenolic acids are major components of cell walls in wheat and have important implications on human health as antioxidants with anti-tumor activity. Our objectives were to identify phenolic acid genes in wheat by single nucleotide polymorphisms (SNPs) detected within the coding sequences of candidate genes, and to identify chromosomal regions associated with single phenolic acids and total soluble phenolic compounds. A set of candidate genes involved in the biosynthesis of hydroxycinnamic acid derivatives were identified by comparative genomics. SNPs found in the coding sequences of six genes (PAL1, PAL2, C4H, C3H, COMT1 and COMT2) were used to determine their chromosomal location and accurate map position on two reference consensus linkage maps. The genome-wide association study (GWAS), based on genotyping a tetraploid wheat collection with 81,587 gene-associated SNPs, detected 22 quantitative trait loci (QTL) distributed on almost all durum wheat chromosomes. Two QTL for p-coumaric acid were coincident with the phenylalanine ammonia-lyase (PAL2) and p-coumarate 3-hydroxylase (C3H) genes on chromosome arms 2AL and 1AL, respectively. The availability of candidate gene-based markers can allow elucidating the mechanism of phenolic acids accumulation in wheat kernels and exploiting the genetic variability of phenolic acids content for the nutritional improvement of wheat end-products.
External Databases	https://doi.org/10.1016/j.jcs.2017.01.022
QTL	[ Hide all but 1 of 22 ] QTL0853_PA-Nigro_et_al__2017_ QTL0842_PA-Nigro_et_al__2017_ QTL0845_PA-Nigro_et_al__2017_ QTL0839_PA-Nigro_et_al__2017_ QTL0859_PA-Nigro_et_al__2017_ QTL0855_PA-Nigro_et_al__2017_ QTL0857_PA-Nigro_et_al__2017_ QTL0843_PA-Nigro_et_al__2017_ QTL0846_PA-Nigro_et_al__2017_ QTL0854_PA-Nigro_et_al__2017_ QTL0844_PA-Nigro_et_al__2017_ QTL0848_PA-Nigro_et_al__2017_ QTL0856_PA-Nigro_et_al__2017_ QTL0850_PA-Nigro_et_al__2017_ QTL0838_PA-Nigro_et_al__2017_ QTL0849_PA-Nigro_et_al__2017_ QTL0847_PA-Nigro_et_al__2017_ QTL0851_PA-Nigro_et_al__2017_ QTL0858_PA-Nigro_et_al__2017_ QTL0840_PA-Nigro_et_al__2017_ QTL0841_PA-Nigro_et_al__2017_ QTL0852_PA-Nigro_et_al__2017_

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