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GrainGenes Reference Report: TAG-92-524

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Reference	TAG-92-524
Title	Estimation of unbiased recombination values in the presence of misclassification of a trait using RFLP maps
Journal	Theoretical and Applied Genetics
Year	1996
Volume	92
Pages	524-531
Author	Cheng R Takano Y Saito A Ukai Y
Abstract	The effect of misclassification of phenotypes of a trait on the estimation of recombination value was investigated The effect was larger for closer linkage If a locus is dominant and linked with the misclassified trait locus in the repulsion phase, then the effect on the recombination value between the two loci is largest A method for estimating the unbiased recombination value and the misclassification rate using maximum likelihood associated with an EM algorithm is also presented. This method was applied to a numerical example from rice genome data. It was concluded that the present method combined with the metric multi-dimensional scaling method is useful for the detection of misclassified markers and for the estimation of unbiased recombination values.
Keyword	[ Hide all but 1 of 18 ] algorithms chromosome-maps estimation gene-mapping genetic markers linkage linkage-groups linkage-maps loci maximum-likelihood misidentification molecular-mapping oryza sativa phenotype quantitative-traits recombination restriction fragment length polymorphism unbiased-estimates

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