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GrainGenes Reference Report: PPS-125-1293

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Reference	PPS-125-1293
Title	Mutator transposase is widespread in the grasses
Journal	Plant Physiology
Year	2001
Volume	125
Pages	1293-1303
Author	Lisch DR Freeling M Langham RJ Choy MY
Abstract	Summary: Although the Mutator (Mu) system is well characterized in maize (Zea mays), very little is known about this highly mutagenic system of transposons in other grasses. Mutator is regulated by the MuDR class of elements, which encodes two genes, one of which, mudrA, has similarity to a number of bacterial transposases. Experiments in our laboratory, as well as database searches, demonstrate that mudrA sequences are ubiquitous and diverse in the grasses. In several species it is clear that multiple paralogous elements can be present in a single genome. In some species such as wheat (Triticum aestivum) and rice (Oryza sativa), mudrA-similar sequences are represented in cDNA databases, suggesting the presence of active Mu transposon systems in these species. Further, in rice and in sorghum, mudrA-like genes are flanked by long terminal inverted repeats, as well as the short host sequence direct repeats diagnostic of insertion. Thus, there is ample evidence that systems related to Mu in maize are at least potentially active in a wide variety of grasses. However, the mudrB gene, though important for Mu activity in maize, is not necessarily a component of Mu elements in other grasses
External Databases	Pubmed: 11244110
Keyword	[ Hide all but 1 of 33 ] bacterial cdna database direct repeat element element system elements evolution gene genome horizontal transfer host insertion inverted repeat maize mays mua2 multiple mura oryza sativa regulator repeat repeats rice search sequence single sorghum transposon transposons triticum aestivum zea zea mays

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