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GrainGenes Reference Report: BBR-219-290

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Reference	BBR-219-290
Title	A major wheat allergen has a Gln-Gln-Gln-Pro-Pro motif identified as an IgE-binding epitope
Journal	Biochemical and Biophysical Research Communications
Year	1996
Volume	219
Pages	290-293
Author	[ Hide all but 1 of 6 ] Tanabe S Arai S Yanagihara Y Mita H Takahashi K Watanabe M
Abstract	The minimum primary structure of the IgE-binding epitope in wheat gluten was determined as Gln-Gln-Gln-Pro-Pro The N-terminal glutamine and the two proline residues were essential for epitopic function The occurrence of the second glutamine residue and acetylation of the N-terminal amino group were found to exert some auxiliary functions, whereas only a lesser contribution was expected for the third glutamine residue It was also been confirmed that acetyl-Gln-Gln-Gln-Pro-Pro bound to wheat-specific IgE antibodies in the sera of patients allergic to wheat, although it did not induce histamine release from the basophils of these patients Taken together, we concluded that the Gln-Gln-Gln-Pro-Pro motif constituted an IgE-binding rather than immunogenic epitope and also that acetyl-Gln-Gln-Gln-Pro-Pro might act as a hapten capable of binding to specific IgE molecules The possibility exists that this peptide will have practical application to therapy for or prevention of wheat-sensitive allergy.
Keyword	allergens [ Show all 7 ]

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